прививка от гепатита B - рост рассеянного склероза в 3 раза

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прививка от гепатита B - рост рассеянного склероза в 3 раза

#1 Сообщение Eug » 15 сен 2004, 09:41

Только что в Neurology опубликовано британское исследование, показавшее, что у привитых от гепатита B рассеянный склероз в течение 3 лет после прививки возникает в 3 раза чаще, чем у остального населения.

Реплика редактора по этому поводу просто гениальна:
"It makes little sense, she says, that the hepatitis B vaccine causes MS when there is no evidence linking the virus to the disease"

Откуда берут таких профессоров? :)
http://my.webmd.com/content/article/94/ ... 13CA348%7D

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#2 Сообщение Eug » 15 сен 2004, 10:03

Вот дайджест самой статьи:

NEUROLOGY 2004;63:838-842
© 2004 American Academy of Neurology

Recombinant hepatitis B vaccine and the risk of multiple sclerosis
A prospective study
Miguel A. Hernán, MD, DrPH, Susan S. Jick, DSc, Michael J. Olek, DO and Hershel Jick, MD
From the Department of Epidemiology (Dr. Hernán), Harvard School of Public Health, Boston; Boston Collaborative Drug Surveillance Program (Drs. Susan S. Jick and Hershel Jick), Boston University, Lexington, MA; and Department of Neurology (Dr. Olek), College of Medicine, University of California, Irvine.

Background: A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations.

Methods: The authors conducted a nested case-control study within the General Practice Research Database (GPRD) in the United Kingdom. The authors identified patients who had a first MS diagnosis recorded in the GPRD between January 1993 and December 2000. Cases were patients with a diagnosis of MS confirmed through examination of medical records, and with at least 3 years of continuous recording in the GPRD before their date of first symptoms (index date). Up to 10 controls per case were randomly selected, matched on age, sex, practice, and date of joining the practice. Information on receipt of immunizations was obtained from the computer records.

Results: The analyses include 163 cases of MS and 1,604 controls. The OR of MS for vaccination within 3 years before the index date compared to no vaccination was 3.1 (95% CI 1.5, 6.3). No increased risk of MS was associated with tetanus and influenza vaccinations.

Conclusions: These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood.

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О том же

#3 Сообщение Александр Коток » 15 сен 2004, 11:34


September 13, 2004

Hepatitis Shot Tied to MS, Study Suggests
Vaccine's association could be statistical fluke, expert says

By Randy Dotinga
HealthDay Reporter

Fueling the continuing debate over the safety of the popular hepatitis B vaccine, a new study suggests that it contributes to a tiny increase in the number of multiple sclerosis cases.

But a neurologist said the results may be a "statistical fluke," and the study authors don't tell adults or children to stop taking the vaccine, which prevents a potentially deadly type of liver disease.

"If you're in a population that is in any way at increased risk for hepatitis B, you should get the vaccine," said study co-author Susan Jick, an associate professor of epidemiology at Boston University. "The risk of getting hepatitis B and dying from it is much higher than the risk of getting MS."

Hepatitis B, spread through blood and body fluids, can lead to cirrhosis -- scarring of the liver -- and liver cancer. An estimated 1.25 million Americans are infected, and about 5,000 die of the chronic form of the disease each year.

High-risk groups face transmission through sex or infected needles. They include drug users, people already infected with sexually transmitted diseases, gay men, AIDS patients, and health-care workers.

While the hepatitis B vaccine is considered to be 95 percent effective and is routinely recommended for children and adolescents, it's been dogged by questions about its safety. In 1996, an outbreak of 200 cases of MS and similar diseases in France convinced French officials to stop vaccinating children.

An estimated 250,000 to 350,000 Americans, mostly women, have MS, not to be confused with muscular dystrophy. The disease appears to be triggered by a malfunction of the immune system that causes it to attack the central nervous system.

MS has a wide variety of symptoms, ranging from tingling, numbness, and pain to muscle weakness, impaired balance, and mental problems.

In the new study, researchers examined statistics in a database that has tracked the health of about 3 million residents of Great Britain since 1987. They looked for patients who were first diagnosed with MS between January 1993 and December 2000 and then checked their immunization records.

The results of the study, funded by the National Multiple Sclerosis Society, appear in the Sept. 14 issue of Neurology.

Researchers found the risk of MS grew by three times over the three years after hepatitis B vaccination. On the other hand, 93 percent of those who developed MS had never been vaccinated for hepatitis B. The study didn't calculate the risk of MS among all people who are vaccinated.

Researchers said they don't know whether the vaccine caused MS or made it appear earlier than it would have otherwise, and Jick declined to speculate on why a vaccine that prevents liver disease may contribute to a nerve disease. There is speculation, however, that the immune system plays a role.

It's also possible that other unknown factors could affect the development of MS.

The study didn't definitively connect the vaccine to the disease, but instead only suggested there's a link. And even that link may not actually exist, said Dr. Anne Cross, a neurologist at Washington University in St. Louis who co-wrote an accompanying commentary on the new study.

"This study contradicts several other large studies that did not show an increased risk of MS following the hep B vaccine," she said, "thus raising a question as to whether the results represent a real finding or a statistical fluke."

Should Americans consider curtailing their use of the vaccine, which is routinely given to several groups, including children and gay men? Jick said there's no reason for panic.

"It is important to keep in mind that hepatitis B is a serious disease. It's much more common than MS," she said. "It's always important to take into account the risks and benefits."

* * * * *
История, когда исследователи сами пугаются своих выводов и начинают уверять публику, что не стоит принимать ими обнаруженное слишком всерьёз - не новость. Однако логику в словах проф. Джик о том, что гепатит В - намного более опасная и распространённая болезнь (при том что подавляющее количество населения вообще не относится к группам риска), чем рассеянный склероз, мне обнаружить не удалось. Можно подумать, что нет у людей другого выхода, кроме как выбирать между двумя этими болезнями... Кстати, и "on the other hand, 93 percent of those who developed MS had never been vaccinated for hepatitis B" ни о чем не говорит. Вот если бы они вообще не были привиты - тогда да, можно было бы усомниться, что прививки играют какую-то роль в развитии РС.
Благостью лихость не изоймешь

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#4 Сообщение Spy » 15 сен 2004, 13:00

А как получилось, что под удар попала именно рекомбинантная вакцина от гепатита В? В смысле, почему именно эта :)?

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#5 Сообщение Eug » 15 сен 2004, 13:18

Исходно - был "anecdotal evidence" - эпидемия во Франции после введения вакцины HepB. В данном исследовании был контроль по вакцинации по двум другим прививкам (от столбняка и гриппа) - но там зависимости не обнаружено.
А мне только что в журнал запостила девушка, у которой брат умер от РС - заболел после прививки от оспы.

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#6 Сообщение Александр Коток » 28 сен 2004, 08:50

Само собой, во Франции эта публикация не осталась незамеченной. Там подан иск против трёх министров здравоохранения, разрешивших использование вакцины, которая привела к вспышке РС в стране.

French health ministers sued over hepatitis vaccine

PARIS, Sept 27 (AFP) - French Health Minister Philippe Douste-Blazy and two of his predecessors in the post have been sued for authorising a vaccine against hepatitis B which plaintiffs say caused multiple-sclerosis in family-members, justice officials said Monday.

The suit was filed on Friday at the Court of Justice of the Republic, the only body authorised to try government ministers for alleged offences committed in the carrying out of their functions.

Douste-Blazy was health minister for a first time in 1994 when a campaign was held to vaccinate 20 million people against hepatitis B.

He and his successors - Bernard Kouchner and Jean-Francois Mattei - are accused of endangering life, providing false information and non-assistance to a person in peril.

Lawyer Gisele Mor, who presented the suit, said she was representing five families - including the parents of two children who died after being given the vaccine.

Allegations that the vaccine might cause multiple-sclerosis resurfaced recently with the publication of a study in the US journal Neurology which claimed there was a statistical link between the two.

Several writs have already been presented to the French courts, but this is the first targeting ministers.

The Court of Justice of the Republic was set up in 1993 to try ministers accused of criminal oversight in allowing blood contaminated with the Aids virus be used for transfusions.
Благостью лихость не изоймешь

Jean Pierre

Hepatitis B side effets in France

#7 Сообщение Jean Pierre » 20 мар 2005, 15:59

Be the first to know !
Get connected to the French Website of the Association REVAHB, and get the latest informations about HEPATITIS B side effects vaccination.
Click hereafter and welcome to the new "Forum" in French or English .

http://www.revahb.org/doc/prive/index2. ... _principal

Jean Pierre


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